Spanish conquest of the Inca Empire: Sapa Inca emperor Manco Inca Yupanqui's army began a ten-month siege of Cusco.

The Spanish conquest of the Inca Empire, also known as the Conquest of Peru, was one of the most important campaigns in the Spanish colonization of the Americas. After years of preliminary exploration and military skirmishes, 168 Spanish soldiers under conquistador Francisco Pizarro, along with his brothers in arms and their indigenous allies, captured the last Sapa Inca, Atahualpa, at the Battle of Cajamarca in 1532. It was the first step in a long campaign that took decades of fighting but ended in Spanish victory in 1572 and colonization of the region as the Viceroyalty of Peru. The conquest of the Inca Empire, led to spin-off campaigns into present-day Chile and Colombia, as well as expeditions to the Amazon Basin and surrounding rainforest.