The Spanish Armada, with 130 ships and 30,000 men, sets sail from Lisbon, Portugal, heading for the English Channel. (It will take until May 30 for all ships to leave port.)

The Spanish Armada was a Spanish fleet that sailed from Lisbon in late May 1588, and was the largest engagement of the undeclared Anglo-Spanish War. The Armada was commanded by Alonso de Guzmán, Duke of Medina Sidonia, an aristocrat appointed by Philip II of Spain. His orders were to sail up the English Channel, join with the army of Alexander Farnese, Duke of Parma in Flanders, and escort an invasion force that would land in England and overthrow Elizabeth I. Its purpose was to reinstate Catholicism in England, end English support for the Dutch Republic in the north and prevent attacks by English and Dutch privateers against Spanish interests in the Americas.