The Vellore Mutiny is the first instance of a mutiny by Indian sepoys against the British East India Company.

The Vellore mutiny, or Vellore Revolution, occurred on 10 July 1806 and was the first instance of a large-scale and violent mutiny by Indian sepoys against the East India Company, predating the Indian Rebellion of 1857 by half a century. The revolt, which took place in the Indian city of Vellore, lasted one full day, during which mutineers seized the Vellore Fort and killed or wounded 200 British troops. The mutiny was subdued by cavalry and artillery from Arcot. Total deaths amongst the mutineers were approximately 350; with summary executions of about 100 during the suppression of the outbreak, followed by the formal court-martial of smaller numbers.