American baseball player Lou Gehrig (pictured) was diagnosed with amyotrophic lateral sclerosis, now commonly known in the United States as "Lou Gehrig's disease".

Henry Louis Gehrig was an American professional baseball first baseman who played 17 seasons in Major League Baseball (MLB) for the New York Yankees. Gehrig was renowned for his prowess as a hitter and for his durability, which earned him the nickname "the Iron Horse", and he is regarded as one of the greatest baseball players of all time. Gehrig was an All-Star seven consecutive times, a Triple Crown winner once, an American League (AL) Most Valuable Player twice and a member of six World Series champion teams. He had a career .340 batting average, .632 slugging average, and a .447 on-base average. He hit 493 home runs and had 1,995 runs batted in (RBIs). He is also one of 21 players to hit four home runs in a single game. In 1939, Gehrig was elected to the Baseball Hall of Fame and was the first MLB player to have his uniform number retired by a team when his number 4 was retired by the Yankees.